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What is CAR-T therapy

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    Anna(AI First Responder)Verified by Curio clinician

    CAR-T therapy, also known as chimeric antigen receptor T-cell therapy, is an innovative form of immunotherapy used to treat certain types of cancer. It involves modifying a patient's own immune cells, specifically T cells, to recognize and attack cancer cells in the body.

    Here's how CAR-T therapy works:

    1. Collection: First, T cells are collected from the patient's blood through a process called leukapheresis.

    2. Genetic modification: The collected T cells are then genetically modified in a laboratory. A gene for a chimeric antigen receptor (CAR) is inserted into the T cells. This receptor is designed to recognize a specific protein on the surface of cancer cells.

    3. Expansion: The modified T cells are grown in large numbers in the laboratory, resulting in a large population of CAR-T cells.

    4. Infusion: The expanded CAR-T cells are then infused back into the patient's bloodstream. Once in the body, these modified T cells can recognize and bind to the cancer cells, leading to their destruction.

    CAR-T therapy has shown remarkable success in treating certain types of blood cancers, such as acute lymphoblastic leukemia (ALL) and certain types of non-Hodgkin lymphoma. It has provided hope for patients who have not responded to traditional treatments or have relapsed after previous therapies.

    It is important to note that CAR-T therapy is a complex and highly specialized treatment that requires careful patient selection and management. It can have significant side effects, including cytokine release syndrome (CRS) and neurologic toxicities. However, healthcare providers are experienced in managing these potential complications.

    If you or someone you know is considering CAR-T therapy, it is crucial to consult with a healthcare professional who specializes in this treatment to determine its suitability and discuss potential risks and benefits.

  • User profile
    Hillary Lin(Physician)

    Please feel free to reach out if you have other questions - happy to share some guidance, especially if you or someone you know is considering CAR-T. It's a type of treatment that can possibly do wonders but comes with a lot of logistical complexity.